Learn about all the current Low AMH treatment options.
Modern Medicine, IVF, Pharmaceuticals
- 10 years ago IVF centres preferred not to treat women with Low AMH because success rates were terrible.
- If you got a diagnosis of low AMH then you have about a 2 – 5% chance of falling pregnant with IVF and almost no chance of falling pregnant naturally.
- Modern medicine has no treatment to improve Low AMH or improve Egg quality.
Chinese Herbal Medicine
- Ovance & RPM have been clinically trialled in over 400 women showing strong increases in recorded AMH levels and higher rates of pregnancy and currently holds the best level of evidence of a viable treatment for low AMH levels with real world outcomes.
- Naturopathy has pharmaceutical chemicals in the form of supplements such as NAC (N-Acetylcysteine) that appear to prevent eggs from ageing as fast in mice. Some studies suggest it as an alternative to metformin for women with PCOS. Actual studies on humans have very small sample sizes and record no actual improvement in AMH levels or increase in pregnancy rates.
- DHEA is proven to assist in improving IVF outcomes for women who respond poorly to IVF drugs with fewer than 5 eggs harvested. Take DHEA for 16 weeks prior to another IVF cycle and your chances for falling pregnant go from 5 – 10% up to 25 – 35%. DHEA has not shown an ability to improve outcomes for women classified as ‘very low AMH levels and seems to work best for women 0.8 ng/ml (or 5.7 pmol/l) and above.
- CoQ10 is suggested to help as well but studies have only been performed on aged mice. CoQ10 begins to naturally decline from the age of 30 onwards and is believe to be linked to ageing and is certainly necessary for mitochondrial activity in cells. CoQ10 is suggested to help as well but studies have only been performed on aged mice. One promising study showed great improvements in primordial, primary and secondary follicles suggesting that CoQ10 can indeed improve the amount of follicles in aged mice. It is also very promising for reducing chromosomal and spindle defects in aged eggs of mice too. No study has shown an improvement of increased pregnancy rates for women with low AMH, only suggesting less chromosomal damage to the egg during an IVF transfer. The authors of the comprehensive study noted that the 12-16 weeks of using CoQ10 supplements on mice would be the equivalent to a decade in humans.
- PQQ is also suggested by there is no study or scientific evidence anywhere suggesting that it assists with improving egg quality, low AMH levels or increases pregnancy outcomes. Tests have only been performed on mice with antioxidant PQQ being used as a preservative for the eggs of mice overnight to determine if PQQ could sustain the qualities of the eggs. The application of PQQ appears better served in storing unused human eggs in IVF transfer than being taken as a supplement to improve fertility in women.
- Vitamin D is believed to play a role in AMH regulation. The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels. If you have low AMH levels getting tested for vitamin D2 and D3 deficiency is a smart thing to do before buying the supplement. Evidence-based research has not proven a significant difference so far in ovulation stimulation or embryo development depending on vitamin D level. Women with levels of Vitamin D of 267.8 ± 66.4 nmol/L show a 4 times better success rate with IVF procedure than those with low levels of 104.3 ± 21 nmol/L.
- Eating healthy is always a smart way to treat your body but there is no good science on any type of food that has been shown to improve egg quality, egg pick up rates for IVF or improve low AMH levels at all. As this a page based on recommendations from different health professions based on actual scientific research, food cannot be commented on here due to lack of actual evidence. If you believe this to be in error we would love to hear your input.